Dispense 1/3 of the ampoule into the palm of your hand and massage it over the face, neck, and eye contours, avoiding contact with eyes. Allow serum to be absorbed into your skin for 30-60 seconds before applying the rest of your skin care routine. Place the cap back onto the applicator tip to preserve the formula until the next application. Use within 48 hours after opening. For more information, please read the instructions inside the box. Use only as directed. For external use only. Do not drink. Do not inject. Keep out of reach of children. Avoid contact with eyes. This ampoule is made of glass. Handle with care to avoid any risk of cutting. When it is empty, throw the ampoule away into the recycling bin, then rinse the plastic applicator and let dry, ready for the next use. * you can use this product alone or after dermaroller. Use a dermaroller with 0.5 mm or smaller needles by avoiding contact with the eye area and following how to use instruction of your dermaroller. It is suggested to do dermarolling before going to bed in order to let your skin enough time to get rest.